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The ethanol extract of the fruit of Solanum nigrum L. Solanaceae was studied for its neuropharmacological properties on experimental animals. The observations suggest that the fruit of S. The preparations of Solanum nigrum L. This extract also showed larvicidal activity against larvae of two mosquito species, Aedes caspius and Culex pipiens , LC 50 Sunlight, pH, and turbidity did not affect the activity of this extract, but diluted solutions of this extract lost their activity after four weeks Allelopathic effect of four plant specieswere examined on seedling growth of certain commonly used varieties of wheat Triticum aestivum L.
On the basis of the present results, UP and WH followed by PBW, Sangam and HD were more susceptible to all the four weed extracts compared to the rest of the varieties of wheat Nightshade berries containing glycoalkaloids can be a contaminant in green peas. Methodology was developed to detect this contamination.
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None of the samples contained alpha-solasonine. No unripe berries of Solanum nigrum were detected visually in the samples The present study based on ethnomedicine survey covers the Dharwad district of Karnataka in southern India. It was revealed that 35 plants belonging to 26 families are being used to treat different types of oral ailments like toothache, plaque and caries, pyorrhea and aphthae.
Sixteen of these plants were new claims for the treatment of oral ailments not previously reported in the ethnomedicinal literature of India and Solanum nigrum are used to treat tooth ache are used in the treatment of plaque and caries The most safe species and what are the toxic ones unsafe. Obtaining results is relied on the interviewee's personal information and the medicinal use of specific plants Studies using the medicinal plants enumerated in this study, particularly those with high number of citations and high F IC values might yield some novel prototypes.
Such studies will also be useful to assess the efficacy and safety of these herbal treatments to take decisions on the health care of rural India Phytochemical and biochemical studies: Phytochemical studies was performed on bioactivity-guided fractionation, three known steroidal glycosides, beta 2-solamargine, solamargine, and degalactoti-gonin, were isolated from Solanum nigrum. The structures of were elucidated on the basis of chemical evidence and spectral analysis, especially by 2D-NMR analysis Two new steroidal saponins, named nigrumnins I and II, together with two known saponins were obtained from the whole plant of Solanum nigrum L.
The importance of the glycolytic flux for the success of Biomphalaria-Schistosome sporocyst interaction was acertained in this study. Hexokinase HK , pyruvate kinase PK. Treatment with this plant resulted in a significant inhibition of these three investigated enzymes.
LC 10 concentrations of S. A rapid, easy, and simple spectrophotometric method was developed for the estimation of total alkaloids precipitated by Dragendorff's reagent DR in plant materials.
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It is based on the formation of yellow bismuth complex in nitric acid medium with thiourea. Using this method, in eight plant species is used in this process the alkaloidal percentage of certain alkaloids itcan be used for routine analysis of commercial samples by industries dealing with herbal drugs for standardization of plant materials containing alkaloids and for alkaloid-containing pharmaceutical products Besides the quantification of such a process, the development of tools is necessary in order to allow the identification of the primary cause of its development and localization ROS-mediated peroxidation was mainly driven by light and always appeared as a late process The study on the absorption and accumulation of heavy metals lead, zinc, copper and cadmium by 8 plant species around a smelter showed that the metals accumulation by plants differed with plant species, their parts, and kinds of metals.
Abutilon theophrasti had a higher capability of absorbing and accumulating Pb. These plants had TF values higher than 1, and were suitable for phytoextraction to remedy polluted soil This paper deals with the isolation and structural characterisation of pregnane glycosides from S. The constituents were isolated and identified by spectral methods. In this study carried out investigation some scientist study based on wild vegetables play an important role in the diet of inhabitants of different parts of the world. All the vegetables had comparatively lower concentrations of phytate, alkaloids and saponins Being able to rapidly and sensitively detect specific enzymatic products is important when screening biological samples for enzymatic activity.
The developed platform can be modified to screen novel protease inhibitors, namely, those potentially useful for treating or preventing infection by viruses, including HIV and hepatitis C To further demonstrate the biological relevance of the SnHypSys peptides, the early defense gene lipoxygenase D was shown to be induced by all three synthetic peptides when supplied to excised nightshade plant Phytochemical analysis of Solanum nigrum has resulted in the isolation of two novel disaccharides.
This study based on Solanum nigrum L. SN has exhibited multiple biological effects such as anti-inflammation and antiproliferation. Protein kinase C PKC regulates cellular functions including proliferation, migration, and invasion. In the present investigation, our results revealed the antimigration and anti-invasion effects of both extracts derived from SN, which may act as a promising therapeutic agent for the treatment of hepatocellular carcinoma To study the chemical constituents from Solanum nigrum.
Their structures were identified by physicochemical properties and spectral analysis. Compounds I - III are isolated from this genus for the first time, while compounds IV and V are isolated from this plant for the first time Solanaceae , a traditional Chinese medicine TCM , has been used for cancer therapy. It is urgent to develop a novel quality standard to validly detect its quality.
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To control its quality, a novel, accurate and valid fingerprint method was developed by high-performance liquid chromatography-evaporative light scattering detection HPLC-ELSD in the current case. So, in order to get the consistent raw materials, the collecting location and the harvesting time should be fixed A new method for simultaneous determination of solasonine 1 , solamargine 2 and khasianine 3 in Solanum nigrum by reversed-phase HPLC was developed.
The method is rapid, simple and accurate, and it can be used for the evaluation of S. A new characteristic steroidal glycoside possessing a hydroxyl group at C, inunigroside a 1 , was isolated from the withered berries of S. I this study18 plant species, Solanum nigrum, was evaluated and discussed.
The sensitivity of the keratinophilic fungi was evaluated by dry-weight method Prosystemin is the precursor protein of the 18 amino acid wound signal systemin which activates systemic defense in tomato leaves against insect herbivores McGurl B, Pearce G, Orozco-Cardenas M, Ryan CA, Science Here, we report the isolation of cDNA sequences encoding prosystemin from potato Solanum tuberosum , black nightshade S.
The accumulation of proteinase inhibitor mRNA transcripts could be induced in each of these plants by treatment with the homologous systemin. As in the tomato, in potato, black nightshade, and bell pepper plants, prosystemin homologs appear to function as precursors of systemic wound signals In black nightshade Solanum nigrum L.
Electrolyte leakage, measured by the conductivity increase in the culture medium Toxicity of plant extracts was also affected by other seasonal dependent factors. These are the duration of plant exposure to direct sunlight and the size of the fruits. Squamous cell carcinoma of the esophagus is endemic in parts of South Africa.
Previous case-control studies have shown many associations but no clear etiologic pathway has been established. Solanum nigrum, beans, and pumpkin all contain protease inhibitors. Suppression of protease inhibitors can lead to overexpression of growth factors in the esophagus, resulting in a proliferative and oncogenic drive The molluscicidal properties of Solanum nigrum L. Gigantica The presence of plant extracts of Solanum nigrum and Cichorium intybus in the reaction mixture containing calf thymus DNA and free radical generating system protect DNA against oxidative damage to its deoxyribose sugar moiety.
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These studies suggest that the observed hepatoprotective effect of these crude plant extracts may be due to their ability to suppress the oxidative degradation of DNA in the tissue debris A study of patients with cancer of the esophagus and controls matched for sex, age, and educational level was done in Transkei, with extensive inquiries into diet and social habits. The significant risk factors found were use of Solanum nigrum as a food relative risk, 3. Consumption of traditional beer was not a risk factor Wistar albino female rats were maintained for 10 d on diets containing various levels of the vegetable Solanum nigrum.
Simultaneously, they received daily intraperitoneal injections of aflatoxin B1 AFB1 either 0. Similar results were obtained with glutathione S-transferase EC 2. Antiulcerogenic activities of three plant drugs were studied against aspirin-induced gastric ulcers in rats. The activity may be due to inhibition of acid and pepsin secretions and their in vitro ability to bind these.
Idea of India wasn’t demolished at Ayodhya. That happened in our ‘liberal’ homes
Brassica oleracea leaf powder did not affect the ulcer index significantly but its aqueous extract lowered the index. This suggests that its antiulcerogenic effect is due to decreases of acid and pepsin outputs which enhance gastric mucosal strength. The reference drug gefarnate decreased the ulcer index by increasing the hexosamine level only. A group of scientist studies based on phytoecdysteroids agonists are widely distributed in the plant world, but solanaceous species have not been extensively examined for their presence.
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We have now surveyed species of solanaceous plants for the presence of ecdysteroid agonist and antagonist activities using the Drosophila melanogaster B II cell line bioassay. Each of the phytoecdysteroid-accumulating species examined Browallia speciosa, Nierembergia hippomanica var violacea, N. Cytotoxicity was significantly inhibited as assessed by the Trypan blue exclusion assay and mitochondrial dehydrogenase activity MTT assay. The test extract also exhibited significant hydroxyl radical scavenging potential, thus suggesting its probable mechanism of cytoprotection Some reschers on studied the susceptibility or resistance of Solanum capsicastrum Link.
Et Schauer , S. Malacoxylon Sendt. Out of the species, S. Solanum comatum and S. Symptoms necrotic lesions, mosaic and chlorosis could be seen after inoculation and the absorbance values DAS-ELISA exceeded twice that of the healthy control samples during the serological tests The plant Solanum nigrum treated with the pathogen Phytophthora infestans-derived elicitor responded by elevated reactive oxygen species ROS production, lipid peroxidation and lipoxygenase activity in comparison with control plants indicating that oxidative stress took place. It is postulated that PQ may be associated with mechanisms maintaining a tightly controlled balance between the accumulation of ROS and antioxidant activity that determines the full expression of effective defence Somatic hybrids between the cultivated potato diploid hybrid clone, ZEL, and hexaploid non-tuber-bearing wild species Solanum nigrum L.
The most vigorous flowering somatic hybrids were selected for assessment of the late-blight resistance SNL has been traditionally used as a herbal plant, whosefruit is believed to have anti-tumor properties, although the mechanism for the activity remains to be elucidated. Collectively, our findings suggest that SNL fruit extract could be used as an anti-oxidant and cancer chemo-preventive material This study based on the plant Solanum nigrum and other plant species is involved in this process and all activities based on the plant and animal species.
Alkaline phosphatase ALP and total bilirubin. The histopathological changes of liver sample in treated animals were compared with respect to control Molluscicidial activity of leaves of Acanthus mollis against Biomphalaria alexandrina was evaluated. A binary combination of A. A tertiary combination of A.
Also, petroleum ether extract of A. Mortality increased with increasing exposure time and concentration SNL has been traditionally used as an herbal plant for a long time. In the present study, SNL glycoprotein showed a dose-dependent radical scavenging activity on radicals, including 1, 1-diphenylpicrylhydrazyl DPPH radicals, hydroxyl radical OH , and superoxide anion O 2 -. Virus-induced gene silencing VIGS has been used routinely in Nicotiana benthamiana to assess functions of candidate genes and as a way to discover new genes required for diverse pathways, especially disease resistance signalling.
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VIGS has recently been shown to work in Arabidopsis thaliana and in tomato. Silencing of R1, Rx and RB successfully attenuated R-gene-mediated disease resistance and resulted in susceptible phenotypes in detached leaf assays. Thus, the VIGS system is an effective method of rapidly assessing gene function in potato This study was carried out to investigate the anticancer effects of a kDa glycoprotein isolated from Solanum nigrum L. For spontaneously induced tumor promotion, dose-dependent cytotoxic and apoptosis-inducing effects at low concentrations.
For experimentally induced tumor promotion collectively, these results suggest that SNL glycoprotein can induce apoptosis through the modulation of signal mediators. Therefore, we speculate that it could be used as a chemotherapy agent even at low concentrations in HCT cells Screening was done of some plants of importance in the Ayurvedic system of traditional medicine used in India to treat enteric diseases. Fifty four plant extracts methanol and aqueous were assayed for their activity against multi-drug resistant Salmonella typhi.
Strong antibacterial activity was shown by the methanol extracts of ten medicinal plants. Moderate antimicrobial activity was shown by Solanum nigrum and other herbs of interest This study was carried out to investigate the modulation of detoxicant enzyme activity and plasma lipidemic levels by kDa glycoprotein isolated from Solanum nigrum Linn.
Therefore, we speculate that SNL glycoprotein can be used as a cholesterol-lowering agent even at low Concentration SNL has been used in folk medicine for its anti-inflammatory activity. A crude water extract of Solanum nigrum leaves was used as a chemical attenuate to Schistosoma mansoni cercariae prior to infection of Swiss female mice.
Cercariae were exposed to 2. The effect on the ability of cercariae to penetrate mice skin, as well as, effect on schistosome worm burden after 8 weeks of infection were measured To study cytotoxicity and antineoplastic effect in vitro Solanum nigrum L extract on U U cells were cultured together with the extract of Solanum nigrum L. Cytotoxicity assay was tested by CCK Cell cycle and apoptosis were determined using flow cytometry FCM analysis and cytotoxicity effect on U cells.
The antineoplastic effect of the drug can partly be ascribed to its apoptotic inducing effect Model systems have proven enormously useful in elucidating the biochemical function of plant genes. They analyzed transcriptional responses of two native Solanaceous species to the attack of an herbivore whose elicitors are known not to be influenced by diet.
Given that attack from the same herbivore elicits profoundly different responses in two Solanaceaous taxa, we conclude that blueprints for commonly regulated responses to plant-herbivore interactions appear unlikely Nitric oxide NO is an antitumour molecule produced in activated macrophages and Solanum nigrum is a plant used in oriental medicine to treat tumours. In this study using mouse peritoneal macrophages, these findings suggest that Solanum nigrum increases the production of NO by rIFN-gamma-primed macrophages and NF-kappaB plays a critical role in mediating these effects This study was carried out to investigate apoptotic effects of the glycoprotein SNL glycoprotein, kDa isolated from Solanum nigrum Linne , which has been used as an anti-pyretic and anti-cancer agent in folk medicine.
We found that the SNL glycoprotein consists of carbohydrate These results indicate that SNL glycoprotein causes HT cell death through apoptosis by its ability to modulate anti-apoptotic signals.