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Size and Classification of the Board of Directors. Information Available to Shareholders. Shareholder Meetings. Required Vote for Authorization of Certain Actions.


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Shareholder Action by Written Consent. Amendment of Corporate Charter and Bylaws. Appraisal Rights.

Amendment No. 1 to Form F-4

Indemnification of Officers and Directors. Conflict-of-Interest Transaction s. Loans to Directors and Officers. Shareholder Suits. Rights of Information and Inspection. Stock Repurchases. Takeover Statutes. Disclosure of Interests. American Depositary Receipts. Share Dividends and Other Distributions. Deposit, Withdrawal and Cancellation. Record Dates. Reports and Other Communications. Payment of Taxes. Reclassifications, Recapitalizations and Mergers. Amendment and Termination. Disclosure of Interest in ADSs. Book Depositary. Pre-Release of ADSs. Supervisory Board.

Management Board. Senior Management Management Team.

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Employment Agreements and Change of Control Agreements. German Tax Considerations. Corporate Purpose of Evotec. Registration of Evotec with the Commercial Register.

Capital Increase for the New Shares. Transferability of the New Shares. Share Certificates for the New Shares. Selling Securities Holders.

Admission to the Stock Exchange and Commencement of Listing. Reasons for the Admission to Trading; Costs of the Admission. Designated Sponsor. Paying Agent.

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Annex 1 Agreement and Plan of Merger. Annex 2 Forms of Voting Agreements.

Background

The following are some questions that you, as a stockholder of Renovis, may have and the answers to those questions. These questions and answers may not address all the questions that may be important to you as a holder of Renovis common stock. Table of Contents Q: How can I vote?

When you cast your vote using the proxy card, you also appoint John P. Walker and Jeffrey S. Farrow, or either of them, as your representatives, or proxies, at the Special Meeting. They will vote your shares at the meeting as you have instructed them on the proxy card. Accordingly, if you send in your proxy card, your shares will be voted whether or not you attend the Special Meeting. If you sign and send in your proxy and do not indicate how you want to vote, we will count your proxy as a vote in favor of the adoption of the merger agreement and all other matters lawfully under consideration at the Special Meeting.

You may attend the Special Meeting and vote your shares in person, rather than completing, signing, dating and returning your proxy. If any matters other than the adoption of the merger agreement are properly presented for consideration at the Special Meeting, your proxies will vote, or otherwise act, on your behalf in accordance with their judgment on those matters. South San Francisco, California Renovis is a science-driven, biopharmaceutical company that seeks to discover, develop and commercialize therapeutics for major medical needs in the areas of neurological and inflammatory diseases.

Renovis applies its integrated capabilities in preclinical research and development, including molecular biology, medicinal chemistry, in vitro and in vivo pharmacology, drug metabolism and pharmacokinetics, toxicology and informatics, to identify and select small molecule drug candidates that meet stringent standards for development. Renovis is engaged in an exclusive, worldwide collaboration with Pfizer Inc. Table of Contents capsaicin, for the potential treatment of pain and other major medical needs.

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Neither Evotec nor Renovis has a pharmaceutical drug product approved or on the market. Both companies currently offer research support and possess early stage drug candidates that have the potential for licensing to pharmaceutical and biotechnology companies. General Information; Purpose of the Special Meeting see page Each holder of shares of Renovis common stock outstanding on the record date is entitled to one vote for each share held by such stockholder, exercisable in person or by properly executed and delivered proxy, at the Special Meeting.

The presence of the holders of at least a majority of Renovis common stock outstanding on the record date, whether present in person or by properly executed and delivered proxy, will constitute a quorum for the transaction of business at the Special Meeting. Vote Required see page You are requested to complete and sign the accompanying form of proxy and return it promptly to Renovis in the enclosed postage-paid envelope. When the accompanying form of proxy is returned properly executed, the shares of Renovis common stock represented by it will be voted at the special meeting in accordance with the instructions contained in the proxy.

You may also vote by proxy by telephone or via the Internet as described in the enclosed proxy card. If a proxy is executed and returned without an indication as to how the shares of Renovis common stock represented are to be voted, the Renovis common stock represented by the proxy will be voted for adoption of the merger agreement and for any motion to adjourn for the purpose of soliciting additional proxies. Unless you check the box on your proxy withholding discretionary authority, the proxy holders may use their discretion to. Table of Contents vote on other matters relating to the special meeting.

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If you vote against the proposal to adopt the merger agreement but do not check the box withholding discretionary authority, the proxies could vote your shares for an adjournment or postponement, which is intended to allow additional votes to be solicited for adoption of the merger agreement. If you have instructed a broker, bank or other nominee to vote your shares of Renovis common stock, you must follow the directions received from the broker, bank or other nominee to change your instructions.


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  5. In addition, MacKenzie Partners, Inc. Renovis has agreed to pay MacKenzie Partners, Inc. Renovis will not pay any additional compensation to directors, officers or other employees for such services, but may reimburse them for reasonable out-of-pocket expenses in connection with such solicitation. Renovis will reimburse banks, brokerage firms and other custodians, nominees and fiduciaries for reasonable expenses incurred by them in sending proxy material to Renovis stockholders. The Merger see page You are encouraged to read the entire merger agreement carefully because it is the principal legal document governing the merger.